How To Reduce Sebum Production

Skin oil, known as sebum, is our body's own natural skin moisturizers. Sebum is produced by sebaceous glands in the skin and lubricate the hair follicles. Oil production is determined by our hormones, so we can not easily control how much we produce. While some lasers, such as fractional laser treatment, may improve the tone and texture of the skin and possibly make pores appear less apparent, they do not lessen oil production in the skin.
Excess sebum can be reduced in a number of different ways. The only medication that has been shown to give a long term reduction in oil production is the oral acne medication isotretinoin. If the skin is just oily, the use of oil-free moisturizers, toners, or salicylic acid washes or gels may be an appropriate first step to help remove excess oil from the skin. If there is also acne, you might consider a course of Accutane, which reduces sebum production for approximately two years. 
There are many lasers which have been shown to affect sebaceous gland activity. Most of the lasers used for non ablative laser skin resurfacing were shown to have an effect on sebaceous activity due to their deeply penetrating wavelengths. The longer wavelengths in the infrared region of the light spectrum have deeper penetration in the skin. 
These are lasers in the infrared region including the long-pulsed Nd:YAG lasers, the 1320 nm CoolTouch, and the 1450 nm Smooth beam laser. fractional laser resurfacing can also help reduce sebum.The Smooth beam 1450nm laser will be one of the best lasers to target the oil glands in your skin. This wavelength of light has a nice absorption spectrum by the oil glands thereby shrinking their size and production of oil. 
Thermage is a radiofrequency device which has been shown in clinical studies and histopathology of the skin to target setaceous glands. It is one of the best devices to treat overactive sebaceous glands. Thermage uses radiofrequency electric current which is more deeply penetrating than infrared lasers. Thermage creates more volumetric heating of the tissue resulting in skin tightening compared to the infrared lasers which do not cause as much skin tightening. 
photodynamic therapy(PDT) using Levulan with blue light is also temporary. There may be a more "permanent" cure using high-dose PDT. This is a new procedure using Levulan with high-dose blue light which actually destroys the sebaceous glands. 
In addition to laser treatments, excessive sebum production can be controlled by topical treatments including various over-the-counter cosmoceuticals, salicyclic acid, benzoyl peroxide, sulfur, chemical peels, and prescription medicines such as retinoids.